Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role
in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation …

Aldehyde dehydrogenases (ALDHs) oxidize aldehydes to the corresponding carboxylic
acids using either NAD or NADP as a coenzyme. Aldehydes are highly reactive aliphatic or …

Aldehyde dehydrogenase (ALDH) is an enzyme that participates in important cellular
mechanisms as aldehyde detoxification and retinoic acid synthesis; moreover, ALDH activity …

Chemotherapy in cancer patients is still not satisfactory because of drug resistance. The
main mechanism of drug resistance results from the ability of cancer cells to actively expel …

Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

There has been a new interest in using aldehyde dehydrogenase (ALDH) activity as one
marker for stem cells since the Aldefluor flow cytometry-based assay has become available …

In some types of human cancer, aldehyde dehydrogenases represent stemness markers
and their expression is associated with advanced disease stages and poor prognosis …

Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol
consumption is beneficial to cardiovascular health, heavy drinking often results in organ …