Humanized mice for immune system investigation: progress, promise and challenges
LD Shultz, MA Brehm, JV Garcia-Martinez… - Nature Reviews …, 2012 - nature.com
Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …
and the human immune system have resulted from the development of'humanized'mouse …
Human hemato-lymphoid system mice: current use and future potential for medicine
To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …
Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa …
Y Levy, I Sereti, G Tambussi, JP Routy… - Clinical infectious …, 2012 - academic.oup.com
Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not
fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but …
fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but …
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
H Von Boehmer, C Daniel - Nature reviews Drug discovery, 2013 - nature.com
Abstract Forkhead box P3 (FOXP3)-expressing regulatory T (TReg) cells have a pivotal role
in the regulation of immune responses and in the maintenance of immunological self …
in the regulation of immune responses and in the maintenance of immunological self …
Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
MA Perales, JD Goldberg, J Yuan… - Blood, The Journal …, 2012 - ashpublications.org
Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-
HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in …
HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in …
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
I Serr, RW Fürst, P Achenbach, MG Scherm… - Nature …, 2016 - nature.com
Immune tolerance is executed partly by Foxp3+ regulatory T (Treg) cells, which suppress
autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes …
autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes …
Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients
M Manuel, O Trédan, T Bachelot, G Clapisson… - …, 2012 - Taylor & Francis
Lymphopenia (< 1Giga/L) detected before initiation of chemotherapy is a predictive factor for
death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was …
death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was …
The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment
BK Berges, MR Rowan - Retrovirology, 2011 - Springer
Substantial improvements have been made in recent years in the ability to engraft human
cells and tissues into immunodeficient mice. The use of human hematopoietic stem cells …
cells and tissues into immunodeficient mice. The use of human hematopoietic stem cells …
Decreased T-cell repertoire diversity in sepsis: a preliminary study
F Venet, O Filipe-Santos, A Lepape, C Malcus… - Critical care …, 2013 - journals.lww.com
Objective: Septic syndromes are the leading causes of mortality in intensive care units. In
patients, the occurrence of sepsis-induced immune suppression is associated with delayed …
patients, the occurrence of sepsis-induced immune suppression is associated with delayed …
[HTML][HTML] IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice
PW Denton, T Nochi, A Lim, JF Krisko… - Mucosal …, 2012 - Elsevier
Intestinal immune cells are important in host defense, yet the determinants for human
lymphoid homeostasis in the intestines are poorly understood. In contrast, lymphoid …
lymphoid homeostasis in the intestines are poorly understood. In contrast, lymphoid …