Abstract Background Adverse outcome pathways (AOPs) are conceptual frameworks that
organize knowledge about biological interactions and toxicity mechanisms. They present a …

The finding of low circulating testosterone level in men is relatively frequent. The symptoms
of hypogonadism are very frequent in the aging men. However, the diagnosis of …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Background: Exposure to environmental phenols (eg, bisphenol A, benzophenone-3, and
triclosan) and parabens is widespread in the population. Many of these chemicals have …

Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for
satisfactory sexual performance. It is common, affecting at least 12 million US men. The five …

Treatment for hypogonadism is on the rise, particularly in the aging population. Yet treatment
in this population represents a unique challenge to clinicians. The physiology of normal …

Effective patient care, clinical research, and public health efforts require comparability of
laboratory results independent of time, place, and measurement procedure. Comparability is …

The use of testosterone to treat the symptoms of late-onset hypogonadal men has increased
recently due to patient and physician awareness. However, concerns regarding the effect of …

Context: Low T levels have been associated with ejaculatory dysfunction (EjD) in cross-
sectional studies; however, the efficacy of T replacement in improving EjD has not been …

Purpose: Intratesticular testosterone is essential for spermatogenesis and can only be
reliably measured with invasive testicular sampling. Previous studies have demonstrated …