Irisin: a hope in understanding and managing obesity and metabolic syndrome

LI Arhire, L Mihalache, M Covasa - Frontiers in endocrinology, 2019 - frontiersin.org
White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Three new players in energy regulation: preptin, adropin and irisin

S Aydin - Peptides, 2014 - Elsevier
Homeostasis of energy is regulated by genetic factors, food intake, and energy expenditure.
When energy input is greater than expenditure, the balance is positive, which can lead to …

Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 signaling pathway activation

AI Mazur-Bialy, E Pocheć, M Zarawski - International journal of molecular …, 2017 - mdpi.com
Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of
adipose tissue and it has potentially protective properties in the development of obesity …

Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 …

A Goday, D Bellido, I Sajoux, AB Crujeiras… - Nutrition & …, 2016 - nature.com
Objective: Evaluating the short-term safety and tolerability of a VLCK diet (< 50 g of
carbohydrate daily) in an interventional weight loss program including lifestyle and …

Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index

M Pardo, AB Crujeiras, M Amil, Z Aguera… - International journal …, 2014 - Wiley Online Library
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and
diabetes because it is induced in muscle by exercise, increasing energy expenditure …

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

N Chen, Q Li, J Liu, S Jia - Diabetes/metabolism research and …, 2016 - Wiley Online Library
Irisin, as a new hormone‐like myokine, is discovered in the presence of exercise‐induced
peroxisome proliferator‐activated receptor gamma coactivator‐1‐alpha (PGC‐1α). Which …

Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: A meta‐analysis

J Fox, BV Rioux, EDB Goulet… - … journal of medicine …, 2018 - Wiley Online Library
Irisin is a recently discovered myokine that increases adipocyte metabolism, induces further
“browning” of white adipose tissue, and enhances glucose metabolism. No study has ever …

Chronic exercise training and circulating irisin in adults: A meta-analysis

S Qiu, X Cai, Z Sun, U Schumann, M Zuegel… - Sports medicine, 2015 - Springer
Background Irisin is a newly discovered hormone that is proposed to be a promising
therapeutic target in obesity and type 2 diabetes. It has received remarkable attention …

Irisin inhibits hepatic cholesterol synthesis via AMPK-SREBP2 signaling

H Tang, R Yu, S Liu, B Huwatibieke, Z Li, W Zhang - EBioMedicine, 2016 - thelancet.com
Irisin, a myokine released during exercise, promotes browning of subcutaneous adipose
tissue and regulates energy homeostasis. Although exercise constantly reduces blood …

Irisin levels before and after physical activity among school‐age children with different BMI: A direct relation with leptin

B Palacios‐González, F Vadillo‐Ortega… - …, 2015 - Wiley Online Library
Objective Irisin is a novel myokine that seems to mediate the beneficial effects of exercise.
Levels of circulating irisin before and after an 8‐month physical activity program (PAP) in …