Protein quality control in the secretory pathway
Z Sun, JL Brodsky - Journal of Cell Biology, 2019 - rupress.org
Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …
with an elaborate network of molecular chaperones and protein folding facilitators …
CFTR: folding, misfolding and correcting the ΔF508 conformational defect
GL Lukacs, AS Verkman - Trends in molecular medicine, 2012 - cell.com
Cystic fibrosis (CF), the most common lethal genetic disease in the Caucasian population, is
caused by loss-of-function mutations of the CF transmembrane conductance regulator …
caused by loss-of-function mutations of the CF transmembrane conductance regulator …
Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots
MicroRNA399-mediated regulation of the ubiquitin-conjugating enzyme
UBC24/PHOSPHATE2 (PHO2) is crucial for Pi acquisition and translocation in plants …
UBC24/PHOSPHATE2 (PHO2) is crucial for Pi acquisition and translocation in plants …
Ubiquitin-dependent sorting in endocytosis
When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs
them through a series of sorting steps that culminate in their delivery to the lumen of the …
them through a series of sorting steps that culminate in their delivery to the lumen of the …
Structure-guided combination therapy to potently improve the function of mutant CFTRs
Available corrector drugs are unable to effectively rescue the folding defects of CFTR-ΔF508
(or CFTR-F508del), the most common disease-causing mutation of the cystic fibrosis …
(or CFTR-F508del), the most common disease-causing mutation of the cystic fibrosis …
Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane
Numerous drugs and endogenous ligands bind to cell surface receptors leading to
modulation of downstream signaling cascades and frequently to adaptation of the plasma …
modulation of downstream signaling cascades and frequently to adaptation of the plasma …
CFTR: a new horizon in the pathomechanism and treatment of pancreatitis
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that
conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the …
conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the …
[HTML][HTML] Quality control and fate determination of Hsp90 client proteins
MA Theodoraki, AJ Caplan - … et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
Quality control processes regulate the proteome by determining whether a protein is to be
folded or degraded. Hsp90 is a hub in the network of molecular chaperones that maintain …
folded or degraded. Hsp90 is a hub in the network of molecular chaperones that maintain …
Chaperone-independent peripheral quality control of CFTR by RFFL E3 ligase
T Okiyoneda, G Veit, R Sakai, M Aki, T Fujihara… - Developmental cell, 2018 - cell.com
The peripheral protein quality control (QC) system removes non-native membrane proteins,
including ΔF508-CFTR, the most common CFTR mutant in cystic fibrosis (CF), from the …
including ΔF508-CFTR, the most common CFTR mutant in cystic fibrosis (CF), from the …
Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator
A Luciani, VR Villella, S Esposito, M Gavina, I Russo… - Autophagy, 2012 - Taylor & Francis
Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance
regulator (CFTR), can be used for the treatment of the small subset of CF patients that carry …
regulator (CFTR), can be used for the treatment of the small subset of CF patients that carry …