Engineering receptor-mediated transmembrane signaling in artificial and living cells
K Shi, C Song, Y Wang, R Chandrawati… - Communications …, 2023 - nature.com
Living cells possess a variety of transmembrane signaling systems that receive chemical
and physical cues from the environment and transduce this information into an intracellular …
and physical cues from the environment and transduce this information into an intracellular …
Death receptors as targets in cancer
Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein
response (UPR)—a signaling network that ultimately determines cell fate. Initially, UPR …
response (UPR)—a signaling network that ultimately determines cell fate. Initially, UPR …
Clustering of death receptor for apoptosis using nanoscale patterns of peptides
The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors
has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can …
has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can …
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity
JD Graves, JJ Kordich, TH Huang, J Piasecki, TL Bush… - Cancer cell, 2014 - cell.com
Death receptor agonist therapies have exhibited limited clinical benefit to date.
Investigations into why Apo2L/TRAIL and AMG 655 preclinical data were not predictive of …
Investigations into why Apo2L/TRAIL and AMG 655 preclinical data were not predictive of …
Self-Illuminating Nanoagonist Simultaneously Induces Dual Cell Death Pathways via Death Receptor Clustering for Cancer Therapy
Y You, L Zhu, Y Song, J Hu, M Chen, J Zhang, X Xu… - ACS …, 2024 - ACS Publications
Inducing death receptor 5 (DR5) clustering holds particular promise in tumor-specific
therapeutics because it could trigger an apoptotic cascade in cancerous cells. Herein, we …
therapeutics because it could trigger an apoptotic cascade in cancerous cells. Herein, we …
Towards novel paradigms for cancer therapy
V Pavet, MM Portal, JC Moulin, R Herbrecht… - Oncogene, 2011 - nature.com
Cancer is a complex progressive multistep disorder that results from the accumulation of
genetic and epigenetic abnormalities, which lead to the transformation of normal cells into …
genetic and epigenetic abnormalities, which lead to the transformation of normal cells into …
Collapsed Star Copolymers Exhibiting Near Perfect Mimicry of the Therapeutic Protein “TRAIL”
Z Han, Z Li, MH Stenzel… - Journal of the American …, 2024 - ACS Publications
Here we introduce amphiphilic star polymers as versatile protein mimics capable of
approximating the activity of certain native proteins. Our study focuses on designing a …
approximating the activity of certain native proteins. Our study focuses on designing a …
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
F Dufour, T Rattier, S Shirley, G Picarda… - Cell Death & …, 2017 - nature.com
Abstract APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells
through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked …
through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked …