[HTML][HTML] Preterm birth: Inflammation, fetal injury and treatment strategies

AK Boyle, SF Rinaldi, JE Norman, SJ Stock - Journal of reproductive …, 2017 - Elsevier
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and
accounts for approximately 11% of births worldwide. Premature babies are at risk of a …

Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Models of fetal brain injury, intrauterine inflammation, and preterm birth

I Burd, B Balakrishnan, S Kannan - American journal of …, 2012 - Wiley Online Library
Intrauterine infection and inflammation are known risk factors for brain damage in the
neonate irrespective of the gestational age. Infection‐induced maternal immune activation …

Antenatal suppression of IL-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice

M Nadeau-Vallée, PY Chin, L Belarbi… - The Journal of …, 2017 - journals.aai.org
MN-V, SP, SAR, SG, and SC designed the research studies; MN-V., P.-YC, LB, M.-ÈB, SP,
MHB, AM, AB-R., DJS, AL-M., XH, A. Boudreault, AC, IB, and SG conducted experiments; …

Fetal immune response to chorioamnionitis

SG Kallapur, P Presicce, CM Rueda… - Seminars in …, 2014 - thieme-connect.com
Chorioamnionitis is a frequent cause of preterm birth and is associated with an increased
risk for injury responses in the lung, gastrointestinal tract, brain, and other fetal organs …

IL‐1 receptor blockade prevents fetal cortical brain injury but not preterm birth in a mouse model of inflammation‐induced preterm birth and perinatal brain injury

K Leitner, M Al Shammary, M McLane… - American journal of …, 2014 - Wiley Online Library
Problem Exposure to intrauterine inflammation, associated with preterm birth, has been
linked to a devastating spectrum of neurobehavioral disorders. Mechanisms of this injury are …

Intrauterine inflammation induces sex-specific effects on neuroinflammation, white matter, and behavior

R Makinson, K Lloyd, A Rayasam, S McKee… - Brain, behavior, and …, 2017 - Elsevier
Exposure to inflammation during pregnancy has been linked to adverse
neurodevelopmental consequences for the offspring. One common route through which a …

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury

J Lei, JM Rosenzweig, MK Mishra, W Alshehri… - Scientific reports, 2017 - nature.com
Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children,
including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been …

Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response

R Romero, P Chaemsaithong, N Docheva… - Journal of perinatal …, 2016 - degruyter.com
Objective: Microbial invasion of the fetus due to intra-amniotic infection can lead to a
systemic inflammatory response characterized by elevated concentrations of cytokines in the …

Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.

TG O'Connor, AA Ciesla, AV Sefair… - … and clinical science, 2022 - psycnet.apa.org
Prenatal maternal infection and anxiety have been linked, in separate lines of study, with
child neurodevelopment. We extend and integrate these lines of study in a large prospective …