[HTML][HTML] Human mesenchymal stem cell therapy for cartilage repair: review on isolation, expansion, and constructs

ATL Lam, S Reuveny, SKW Oh - Stem Cell Research, 2020 - Elsevier
Articular cartilage defects are one of the major challenges in orthopedic and trauma surgery.
However, the poor ability of cartilage to self-repair has motivated efforts to engineer …

Principal criteria for evaluating the quality, safety and efficacy of hMSC-based products in clinical practice: current approaches and challenges

JA Guadix, J López-Beas, B Clares, JL Soriano-Ruiz… - Pharmaceutics, 2019 - mdpi.com
Human Mesenchymal Stem Cells (hMSCs) play an important role as new therapeutic
alternatives in advanced therapies and regenerative medicine thanks to their regenerative …

Hypoxia Conditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Increased Vascular Tube Formation in vitro

C Almeria, R Weiss, M Roy, C Tripisciano… - … in Bioengineering and …, 2019 - frontiersin.org
Mesenchymal stem/stromal cells (MSCs) display a variety of therapeutically relevant effects,
such as the induction of angiogenesis, particularly under hypoxic conditions. It is generally …

Quality control optimization for minimizing security risks associated with mesenchymal stromal cell-based product development

CLK Rebelatto, LM Boldrini-Leite, DR Daga… - International Journal of …, 2023 - mdpi.com
Mesenchymal stromal cells (MSCs) have been considered a therapeutic strategy in
regenerative medicine because of their regenerative and immunomodulatory properties …

Ginsenoside Rg1 as an effective regulator of mesenchymal stem cells

F He, C Yu, T Liu, H Jia - Frontiers in Pharmacology, 2020 - frontiersin.org
Recently, breakthroughs have been made in the use of mesenchymal stem cells (MSCs) to
treat various diseases. Several stem cell types have been authorized as drugs by the …

Mesenchymal stromal cell secretome for post-COVID-19 pulmonary fibrosis: a new therapy to treat the long-term lung sequelae?

E Bari, I Ferrarotti, L Saracino, S Perteghella, ML Torre… - Cells, 2021 - mdpi.com
To date, more than 100 million people worldwide have recovered from COVID-19.
Unfortunately, although the virus is eradicated in such patients, fibrotic irreversible interstitial …

Molecular and functional phenotypes of human bone marrow-derived mesenchymal stromal cells depend on harvesting techniques

SG Walter, TM Randau, C Hilgers… - International journal of …, 2020 - mdpi.com
Mesenchymal stromal cells (MSC) harvested in different tissues from the same donor exhibit
different phenotypes. Each phenotype is not only characterized by a certain pattern of cell …

A nanocomposite hydrogel delivery system for mesenchymal stromal cell secretome

K Shoma Suresh, S Bhat, BR Guru, MS Muttigi… - Stem cell research & …, 2020 - Springer
Background Mesenchymal stromal cell conditioned medium (MSC-CM) contains a cocktail
of bioactive factors that act synergistically to induce therapeutic effects. This has been clearly …

[HTML][HTML] Multiomics analyses of cytokines, genes, miRNA, and regulatory networks in human mesenchymal stem cells expanded in stirred microcarrier-spinner …

ATL Lam, AP Lee, P Jayaraman, KY Tan… - Stem Cell Research, 2021 - Elsevier
Mesenchymal stem cells (MSCs) are of great clinical interest as a form of allogenic therapy
due to their excellent regenerative and immunomodulatory effects for various therapeutic …

Microfluidic separation of canine adipose-derived mesenchymal stromal cells

Z Liu, R Screven, D Yu, L Boxer, MJ Myers… - … Engineering Part C …, 2021 - liebertpub.com
Mesenchymal stromal cells (MSCs) are potential treatments for a variety of veterinary
medical conditions. However, clinical trials have often fallen short of expectations, due in …