Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

Traditional views of nutritional carcinogenesis depend on the identification of exogenous
carcinogens as major risk factors. As our understanding evolves, it is clear that the pattern of …

An increasing literature associates high intake of meat, especially red meat and processed
meat with an increased risk of cancers, especially colorectal cancer. There is evidence that …

Background Exposure to energy restriction during childhood and adolescence is associated
with a lower risk of developing colorectal cancer (CRC). Epigenetic dysregulation during this …

Epigenetic changes in chromatin structure can influence gene expression without affecting
the DNA sequence. The most commonly studied epigenetic modification, DNA methylation …

The developmental origins of adult health and disease (DOHaD) hypothesis that argues for
a causal relationship between under-nutrition during early life and increased risk for a range …

Background How body size influences risk of molecular subtypes of colorectal cancer (CRC)
is unclear. We investigated whether measures of anthropometry differentially influence risk …

Background We investigated how body size and physical activity influence the risk of the
CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). Methods In the …

In this work, possible relationships between global DNA methylation and metal/metalloid
concentrations in earthworms have been explored. Direct correlation was observed between …

Selenium is an essential trace element that has been implicated in cancer risk; however,
study results have been inconsistent with regard to colon cancer. Our objectives were to 1) …