Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …

Protein misfolding and aggregation are implicated in many neurodegenerative diseases.
One of these diseases is Huntington's, which is caused by increased glutamine-encoding …

Design and development of potential pyruvate dehydrogenase kinase 3 (PDK3) inhibitors
have gained attention because of their possible therapeutic uses in lung cancer therapy. In …

Abstract Coronavirus disease 2019 (COVID-19) has emerged from China and globally
affected the entire population through the human-to-human transmission of a newly …

Recent research has advocated the significant contribution of metal dyshomeostasis in
developing and progressing Alzheimer's disease (AD). Disruption of homeostasis creates an …

Morganella morganii is one of the main etiological agents of hospital-acquired infections
and no licensed vaccine is available against the pathogen. Herein, we designed a multi …

Sphingosine kinase 1 (SphK1) is an oncogenic lipid kinase that catalyzes the formation of
sphingosine-1-phosphate via phosphorylation of sphingosine and known to play a crucial …

Aromatic residues can participate in various biomolecular interactions, such as π–π, cation−
π, and CH− π interactions, which are essential for protein structure and function. Here, we re …

Cancer cells change their glucose and glutamine (GLU) metabolism to obtain the energy
required to continue growing. Glutaminase (GLS) plays a crucial role in promoting cell …