At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Time perception is an essential element of conscious and subconscious experience,
coordinating our perception and interaction with the surrounding environment. In recent …

Performance of supercomputers has been steadily and exponentially increasing for the past
20 years, and is expected to increase further. This unprecedented computational power …

The brain functions can be reversibly modulated by the action of general anesthetics.
Despite a wide number of pharmacological studies, an extensive analysis of the cellular …

Neuronal inhibition can be defined as a spatiotemporal restriction or suppression of local
microcircuit activity. The importance of inhibition relies in its fundamental role in shaping …

The cerebellar granule cells (GrCs) are classically described as a homogeneous neuronal
population discharging regularly without adaptation. We show that GrCs in fact generate …

Spike-timing-dependent plasticity (STDP) is a form of long-term synaptic plasticity exploiting
the time relationship between postsynaptic action potentials (APs) and EPSPs. Surprisingly …

Abstract PRoline-Rich Transmembrane protein-2 (PRRT2) is a recently described neuron-
specific type-2 integral membrane protein with a large cytosolic N-terminal domain that …

In realistic neuronal modeling, once the ionic channel complement has been defined, the
maximum ionic conductance (Gi-max) values need to be tuned in order to match the firing …

The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer.
Although recent works have highlighted the complexity of their dendritic organization and …