The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Inflammasomes continue to generate interest in an increasing number of disciplines owing
to their unique ability to integrate a myriad of signals from pathogen‐and damage …

Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

The guanylate binding protein (GBP) family of interferon‐inducible GTP ases promotes
antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps …

Toxoplasmosis is the clinical and pathological consequence of acute infection with the
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …