Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors

I Pitha, L Du, TD Nguyen, H Quigley - Progress in retinal and eye research, 2024 - Elsevier
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Scleral thickness in human eyes

S Vurgese, S Panda-Jonas, JB Jonas - PloS one, 2012 - journals.plos.org
Purpose To obtain information about scleral thickness in different ocular regions and its
associations. Methods The histomorphometric study included 238 human globes which had …

Aging and ocular tissue stiffness in glaucoma

B Liu, S McNally, JI Kilpatrick, SP Jarvis… - Survey of …, 2018 - Elsevier
Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

[HTML][HTML] Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations

MJA Girard, JKF Suh, M Bottlang… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: To characterize scleral biomechanics in both eyes of eight monkeys in which
chronic intraocular pressure (IOP) elevation was induced in one eye. Methods.: Each …

[HTML][HTML] Finite element analysis predicts large optic nerve head strains during horizontal eye movements

X Wang, H Rumpel, WEH Lim… - … & visual science, 2016 - jov.arvojournals.org
Purpose: We combined finite element (FE) analysis and dynamic magnetic resonance
imaging (MRI) to estimate optic nerve head (ONH) strains during horizontal eye movements …

Optic nerve head biomechanics in aging and disease

JC Downs - Experimental eye research, 2015 - Elsevier
This nontechnical review is focused upon educating the reader on optic nerve head
biomechanics in both aging and disease along two main themes: what is known about how …

Collagen structure and mechanical properties of the human sclera: analysis for the effects of age

B Coudrillier, J Pijanka, J Jefferys… - Journal of …, 2015 - asmedigitalcollection.asme.org
The objective of this study was to measure the collagen fiber structure and estimate the
material properties of 7 human donor scleras, from age 53 to 91. The specimens were …

[HTML][HTML] Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae

JK Pijanka, B Coudrillier, K Ziegler… - … & visual science, 2012 - tvst.arvojournals.org
Purpose.: The posterior sclera has a major biomechanical influence on the optic nerve head,
and may therefore be important in glaucoma. Scleral material properties are influenced …

[HTML][HTML] Intraocular pressure, blood pressure, and retinal blood flow autoregulation: a mathematical model to clarify their relationship and clinical relevance

G Guidoboni, A Harris, S Cassani… - … & visual science, 2014 - jov.arvojournals.org
Purpose.: This study investigates the relationship between intraocular pressure (IOP) and
retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow …