Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …
vaccines are highly effective at preventing infection and especially severe disease …
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
Comprehensive mapping of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling
Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become
widespread, providing new insights into the immune system with potential broad clinical and …
widespread, providing new insights into the immune system with potential broad clinical and …
The transcription factor T-bet resolves memory B cell subsets with distinct tissue distributions and antibody specificities in mice and humans
JL Johnson, RL Rosenthal, JJ Knox, A Myles… - Immunity, 2020 - cell.com
B cell subsets expressing the transcription factor T-bet are associated with humoral immune
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy
V Pillai, K Muralidharan, W Meng, A Bagashev… - Blood …, 2019 - ashpublications.org
Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is
approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the …
approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the …
Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
Activating RAS missense mutations are among the most prevalent genomic alterations
observed in human cancers and drive oncogenesis in the three most lethal tumor types …
observed in human cancers and drive oncogenesis in the three most lethal tumor types …
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
E Ricker, M Manni, D Flores-Castro, D Jenkins… - Nature …, 2021 - nature.com
Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …