Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science

MD Rand, JM Tennessen, TFC Mackay… - Current …, 2023 - Wiley Online Library
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the
last decade. The Drosophila model has long been appreciated as a versatile and powerful …

Pleiotropy, epistasis and the genetic architecture of quantitative traits

TFC Mackay, RRH Anholt - Nature Reviews Genetics, 2024 - nature.com
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …

The genetic architecture of behavioral canalization

RRH Anholt, TFC Mackay - Trends in Genetics, 2023 - cell.com
Behaviors are components of fitness and contribute to adaptive evolution. Behaviors
represent the interactions of an organism with its environment, yet innate behaviors display …

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia

C Almodóvar-Payá, M Guardiola-Ripoll… - Brain Structure and …, 2024 - Springer
The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment
and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF) …

Advances in Ajwain Genetics, Genomics, and Breeding: Exploring the Potential for Improved Health and Crop Productivity

RS Tomar, A Vala, S Pandey - Genetics, Genomics and Breeding of Seed …, 2025 - Springer
Ajwain (Trachyspermum ammi), a widely used spice and medicinal herb, has gained
significant attention for its therapeutic properties and agronomic potential. Recent advances …

A Systems Genetics Approach to Drosophila melanogaster Models of Rare and Common Neurodevelopmental Disorders

RA MacPherson - 2023 - search.proquest.com
Abstract Fetal Alcohol Spectrum Disorders are a group of disorders resulting from prenatal
alcohol exposure, presenting with neurodevelopmental and facial abnormalities of varying …