Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of
clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral …

Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-
malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation …

Successful control of falciparum malaria depends greatly on treatment with artemisinin
combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged …

We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into
trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …

The unfolded protein response (UPR) is a network of signaling pathways that responds to
stress in the endoplasmic reticulum (ER). The general output of the UPR is to upregulate …

Information on the growth rate and metabolism of microbial pathogens that cause long-term
chronic infections is limited, reflecting the absence of suitable tools for measuring these …

Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

Early secretory and endoplasmic reticulum (ER)-localized proteins that are terminally
misfolded or misassembled are degraded by a ubiquitin-and proteasome-mediated process …

Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …