Contractility of the myocardium engines the pumping function of the heart and is enabled by
the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on …

Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide,
and move. Both chemical and physical signals orchestrate spreading during normal …

In this study, human embryonic stem cell-derived cardiomyocytes were seeded onto
controlled two-dimensional micropatterned features, and an improvement in sarcomere …

As sarcomeres produce the force necessary for contraction, assessment of sarcomere order
is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by …

Cells respond to both physical and chemical aspects of their substrate. Whether intracellular
signals initiated by physical stimuli are fundamentally different from those elicited by …

Interestingly, in vivo studies demonstrated that only in nonmammalian vertebrates and
during fetal stages of mammalian development, AJ and desmosomes become uniformly …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) can be utilized to
understand the mechanisms underlying the development and progression of heart disease …

Controlling cellular shape with micropatterning extracellular matrix (ECM) proteins on
hydrogels has been shown to improve the reproducibility of the cell structure, enhancing our …

Direct reprogramming of fibroblasts into cardiomyocytes is a promising approach for cardiac
regeneration but still faces challenges in efficiently generating mature cardiomyocytes …

Well-controlled 2D cell culture systems advance basic investigations in cell biology and
provide innovative platforms for drug development, toxicity testing, and diagnostic assays …