Destruction and detection of chemical warfare agents

K Kim, OG Tsay, DA Atwood, DG Churchill - Chemical reviews, 2011 - ACS Publications
This review is shaped in scope by much and various chemical, biological, materials science,
device, and chemical engineering literature. This review is intended to make major …

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… <? ACS-CT-START-Insert?> Jang<? ACS-CT … - Chemical …, 2015 - ACS Publications
Yang and co-workers appeared (Figure 1), 2 and 16 years since their accompanying
Accounts article,“Chemical Detoxification of Nerve Agent VX.” 14 Also, organophosphonate …

Molecularly imprinted porous aromatic frameworks serving as porous artificial enzymes

Y Yuan, Y Yang, M Faheem, X Zou, X Ma… - Advanced …, 2018 - Wiley Online Library
Artificially designed enzymes are in demand as ideal catalysts for industrial production but
their dense structure conceals most of their functional fragments, thus detracting from …

The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents

AN Bigley, FM Raushel - Chemico-biological interactions, 2019 - Elsevier
The organophosphorus chemical warfare agents were initially synthesized in the 1930's and
are some of the most toxic compounds ever discovered. The standard means of …

QM/MM and MM MD Simulations on Enzymatic Degradation of the Nerve Agent VR by Phosphotriesterase

J Yu, Y Fu, Z Cao - The Journal of Physical Chemistry B, 2023 - ACS Publications
V-type nerve agents are hardly degraded by phosphotriesterase (PTE). Interestingly, the
PTE variant of BHR-73MNW can effectively improve the hydrolytic efficiency of VR …

Microbial phosphotriesterase: structure, function, and biotechnological applications

W Latip, VF Knight, N Abdul Halim, KK Ong… - Catalysts, 2019 - mdpi.com
The role of phosphotriesterase as an enzyme which is able to hydrolyze organophosphate
compounds cannot be disputed. Contamination by organophosphate (OP) compounds in …

A comprehensive understanding of enzymatic degradation of the G-type nerve agent by phosphotriesterase: revised role of water molecules and rate-limiting product …

F Fan, Y Zheng, Y Zhang, H Zheng, J Zhong… - Acs Catalysis, 2019 - ACS Publications
Nerve agents are highly toxic organophosphorus compounds, and the wild-type
phosphotriesterase (PTE) enzyme is capable of hydrolyzing these organophosphates but …

Bio-catalytic system of metallohydrolases for remediation of neurotoxin organophosphates and applications with a future vision

H Mali, C Shah, DH Patel, U Trivedi… - Journal of inorganic …, 2022 - Elsevier
Organophosphates (OPs) compounds are universally used as pesticides and maintained as
chemical warfare agents by many nations across the globe. These OPs compounds due to …

Degradation of pesticides diazinon and diazoxon by phosphotriesterase: insight into divergent mechanisms from QM/MM and MD simulations

Y Fu, Y Zhang, F Fan, B Wang, Z Cao - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
Enzymatic hydrolysis by phosphotriesterase (PTE) is one of the most effective ways of
degrading organophosphorus pesticides, but the catalytic efficiency depends on the …

Protein engineering of representative hydrolytic enzymes for remediation of organophosphates

R Iyer, B Iken - Biochemical Engineering Journal, 2015 - Elsevier
Organophosphorus (OP) pesticides are highly effective insecticides used worldwide due to
their low cost and ease of application. OP compounds also form the core of G-series and V …