Copper in tumors and the use of copper-based compounds in cancer treatment

DA da Silva, A De Luca, R Squitti, M Rongioletti… - Journal of inorganic …, 2022 - Elsevier
Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

[HTML][HTML] Recent advances in cancer therapeutic copper-based nanomaterials for antitumor therapy

R Aishajiang, Z Liu, T Wang, L Zhou, D Yu - Molecules, 2023 - mdpi.com
Copper serves as a vital microelement which is widely present in the biosystem, functioning
as multi-enzyme active site, including oxidative stress, lipid oxidation and energy …

[HTML][HTML] Bisphenol A (BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines

C Wang, J He, T Xu, H Han, Z Zhu, L Meng… - Ecotoxicology and …, 2021 - Elsevier
The analogues of biphenol A (BPA), including bisphenol S (BPS) and bisphenol B (BPB),
are commonly used to replace the application of BPA in containers and wrappers of daily …

Hepatoprotective effect of kaempferol: a review of the dietary sources, bioavailability, mechanisms of action, and safety

MY Alkandahri, BT Pamungkas… - Advances in …, 2023 - Wiley Online Library
The liver is the body's most critical organ that performs vital functions. Hepatic disorders can
affect the physiological and biochemical functions of the body. Hepatic disorder is a …

Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells

C Wang, G Nie, F Yang, J Chen, Y Zhuang… - Journal of hazardous …, 2020 - Elsevier
High doses of molybdenum (Mo) and cadmium (Cd) cause adverse reactions on animals,
but the joint toxic effects of Mo and Cd on duck renal tubular epithelial cells are not fully …

Exposure to copper induces mitochondria-mediated apoptosis by inhibiting mitophagy and the PINK1/parkin pathway in chicken (Gallus gallus) livers

F Yang, J Liao, W Yu, N Qiao, J Guo, Q Han, Y Li… - Journal of Hazardous …, 2021 - Elsevier
Copper (Cu), a transition metal with essential cellular functions, exerts toxic effects when
present in excess by inducing oxidative stress. However, the Cu-induced crosstalk between …

[HTML][HTML] mtROS-mediated Akt/AMPK/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264. 7 mouse …

Q Luo, Y Song, J Kang, Y Wu, F Wu, Y Li, Q Dong… - Redox biology, 2021 - Elsevier
Copper (Cu) is a trace element necessary in animals as well as human beings. However,
excessive Cu is toxic to immunocytes, but the precise mechanism is largely unclear so far …

Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults

X Wang, B Wang, M Zhou, L Xiao, T Xu, S Yang… - Journal of Hazardous …, 2021 - Elsevier
Heavy metal exposures have been reported to be associated with increased risk for liver
injury. However, the potential mechanisms of the association remain unclear. A repeated …

[HTML][HTML] Long-term copper exposure promotes apoptosis and autophagy by inducing oxidative stress in pig testis

Y Li, H Chen, J Liao, K Chen, MT Javed, N Qiao… - … Science and Pollution …, 2021 - Springer
Copper (Cu) is a heavy metal which is being used widely in the industry and agriculture.
However, the overuse of Cu makes it a common environmental pollutant. In order to …

[HTML][HTML] Copper in cancer: from limiting nutrient to therapeutic target

X Tang, Z Yan, Y Miao, W Ha, Z Li, L Yang… - Frontiers in …, 2023 - frontiersin.org
As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …