Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

An important goal of biomedical research is to translate basic research findings into useful
medical advances. In the field of neuropharmacology this requires understanding disease …

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White matter (WM) occupies a large volume of the human cerebrum and is mainly composed
of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are …

Many advances have been achieved in terms of understanding the molecular and cellular
mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain …

Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Objective Preclinical evaluation of neuroprotectants fostered high expectations of clinical
efficacy. When not matched, the question arises whether experiments are poor indicators of …