Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives

M Navarro, C Gabbiani, L Messori, D Gambino - Drug discovery today, 2010 - Elsevier
Tropical diseases today constitute a major health problem and a big challenge for drug
discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent …

Thiosemicarbazone metal complexes: from structure to activity

G Pelosi - The Open Crystallography Journal, 2010 - benthamopen.com
Thiosemicarbazones and their metal complexes are compounds that possess antitumor,
antibacterial, antifungal and antiviral properties. For the foremost majority of cases the …

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

A Cavalli, ML Bolognesi - Journal of Medicinal Chemistry, 2009 - ACS Publications
“We have never had such a sophisticated arsenal of technologies for treating diseases, yet
the gap in health outcomes keep getting wider. This is unacceptable.” This claim was made …

Gold complexes as potential anti-parasitic agents

M Navarro - Coordination Chemistry Reviews, 2009 - Elsevier
The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …

Potentiality of vanadium compounds as anti-parasitic agents

D Gambino - Coordination Chemistry Reviews, 2011 - Elsevier
Research efforts on the medicinal chemistry of vanadium have been mainly focused whether
on improving biodistribution and tolerability of the vanadium insulin-enhancing core or on …

Water-soluble mono-and binuclear Ru (η6-p-cymene) complexes containing indole thiosemicarbazones: synthesis, DFT modeling, biomolecular interactions, and in …

J Haribabu, G Sabapathi, MM Tamizh… - …, 2018 - ACS Publications
Indole thiosemicarbazone ligands were prepared from indole-3-carboxaldehyde and N-(un)
substituted thiosemicarbazide. The Ru (η6-p-cymene) complexes [Ru (η6-p-cymene)(HL1) …

Searching for new chemotherapies for tropical diseases: Ruthenium–clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma …

A Martínez, T Carreon, E Iniguez… - Journal of medicinal …, 2012 - ACS Publications
Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have
been synthesized, cis, fac-[RuIICl2 (DMSO) 3 (CTZ)](1), cis, cis, trans-[RuIICl2 (DMSO) 2 …

Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: new achievements

J Benítez, L Becco, I Correia, SM Leal, H Guiset… - Journal of Inorganic …, 2011 - Elsevier
In the search for new therapeutic tools against diseases produced by kinetoplastid parasites
five vanadyl complexes,[VIVO (L-2H)(phen)], including 1, 10-phenanthroline (phen) and …

Novel platinum (II) and palladium (II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic …

A Karaküçük-İyidoğan, D Taşdemir… - European journal of …, 2011 - Elsevier
A series of thiosemicarbazones and their platinum (II) and palladium (II) complexes have
been synthesized. The chemical structures of ligands and their complexes were …