Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the
forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC …

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalently co-
occurring, important risk factors for a broad array of neuropsychiatric diseases. To date, how …

Background The nucleus incertus (NI) was originally described by Streeter in 1903, as a
midline region in the floor of the fourth ventricle of the human brain with an …

Rationale The contribution of norepinephrine on the different phases of spatial memory
processing remains incompletely understood. To address this gap, this study depleted …

Adaptive behavior relies on efficient cognitive control. The anterior cingulate cortex (ACC) is
a key node within the executive prefrontal network. The reciprocal connectivity between the …

The use of designer receptors exclusively activated by designer drugs (DREADDs) has led
to significant advances in our understanding of the neural circuits that govern behavior. By …

Introduction Disruption of metabolic function is a recognized feature of late onset Alzheimer's
disease (LOAD). We sought to determine whether similar metabolic pathways are implicated …

The acoustic startle reflex (ASR) and prepulse inhibition of the ASR (PPI) assess the
efficiency of salience processing, a fundamental brain function that is impaired in many …

There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed
countries, the vast majority of these individuals will develop Alzheimer's disease …