Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

High density lipoprotein (HDL) cholesterol has traditionally been considered the “good
cholesterol”, and most of the research regarding HDL cholesterol has for decades revolved …

There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …

Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …

Importance The balance between the potential long-term clinical benefits and harms
associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Age-related macular degeneration (AMD) is the leading cause of vision loss and visual
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …

The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

Genome-wide association studies (GWASs) of eye disorders have identified hundreds of
genetic variants associated with ocular disease. However, the vast majority of these variants …

Neovascular age-related macular degeneration (nAMD), along with its clinical subtype
known as polypoidal choroidal vasculopathy (PCV), are among the leading causes of vision …