The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …

Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …