The vagus nerve (VN) is the longest nerve of the organism and a major component of the
parasympathetic nervous system which constitutes the autonomic nervous system (ANS) …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

The number of publications investigating heart rate variability (HRV) in psychiatry and the
behavioral sciences has increased markedly in the last decade. In addition to the significant …

Objectives Vagus nerve stimulation (VNS) is reemerging as an exciting form of brain
stimulation, due in part to the development of its noninvasive counterpart transcutaneous …

Objective: The Treatment-Resistant Depression Registry investigated whether adjunctive
vagus nerve stimulation (VNS) with treatment as usual in depression has superior long-term …

Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

The vagus nerve is a major component of the autonomic nervous system, has an important
role in the regulation of metabolic homeostasis, and plays a key role in the neuro-endocrine …

Background Thirty percent of patients with treatment-resistant depression (TRD) attempt
suicide at least once during their lifetime. However, it is unclear what the attempted and …

Background Depression is the most common form of mental disorder in community and
health care settings and current treatments are far from satisfactory. Vagus nerve stimulation …

Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …