Big-data science in porous materials: materials genomics and machine learning

KM Jablonka, D Ongari, SM Moosavi, B Smit - Chemical reviews, 2020 - ACS Publications
By combining metal nodes with organic linkers we can potentially synthesize millions of
possible metal–organic frameworks (MOFs). The fact that we have so many materials opens …

The reign of the p-value is over: what alternative analyses could we employ to fill the power vacuum?

LG Halsey - Biology letters, 2019 - royalsocietypublishing.org
The p-value has long been the figurehead of statistical analysis in biology, but its position is
under threat. p is now widely recognized as providing quite limited information about our …

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS–STING

Y Hou, Y Wei, S Lautrup, B Yang… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Microplastic shape, polymer type, and concentration affect soil properties and plant biomass

YM Lozano, T Lehnert, LT Linck, A Lehmann… - Frontiers in plant …, 2021 - frontiersin.org
Microplastics may enter the soil in a wide range of shapes and polymers. However, little is
known about the effects that microplastics of different shapes, polymers, and concentration …

A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

MJ Tisza, CB Buck - … of the National Academy of Sciences, 2021 - National Acad Sciences
Despite remarkable strides in microbiome research, the viral component of the microbiome
has generally presented a more challenging target than the bacteriome. This gap persists …

Adult-born dentate granule cells promote hippocampal population sparsity

SB McHugh, V Lopes-dos-Santos, GP Gava… - Nature …, 2022 - nature.com
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …

Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults

WE Anthony, B Wang, KV Sukhum, AW D'Souza… - Cell reports, 2022 - cell.com
Antibiotics are deployed against bacterial pathogens, but their targeting of conserved
microbial processes means they also collaterally perturb the commensal microbiome. To …

Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

X Li, J Yang, X Zhou, C Dai, M Kong, L Xie, C Liu… - Nature …, 2024 - nature.com
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …

Raincloud plots: a multi-platform tool for robust data visualization

M Allen, D Poggiali, K Whitaker… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
Across scientific disciplines, there is a rapidly growing recognition of the need for more
statistically robust, transparent approaches to data visualization. Complementary to this …

C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

R Kaletsky, RS Moore, GD Vrla, LR Parsons, Z Gitai… - Nature, 2020 - nature.com
Caenorhabditis elegans must distinguish pathogens from nutritious food sources among the
many bacteria to which it is exposed in its environment. Here we show that a single …