Discovery of a hidden transient state in all bromodomain families
Bromodomains (BDs) are small protein modules that interact with acetylated marks in
histones. These posttranslational modifications are pivotal to regulate gene expression …
histones. These posttranslational modifications are pivotal to regulate gene expression …
Nadolol Attenuates Brain Cell Ferroptosis in Ischemic Stroke Rats by Targeting the HOIL-1/IRP2 Pathway
XY Yang, WJ Zhu, Di-Chen 2, D Peng… - CNS & Neurological …, 2024 - benthamdirect.com
Background: The selective targeting of CREB-cAMP-responsive element-binding protein
(CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant …
(CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant …
Discovery of an EP300 Inhibitor using Structure-based Virtual Screening and Bioactivity Evaluation
D Pan, Y Huang, D Jiang, Y Zhang… - Current …, 2024 - benthamdirect.com
Background: EP300 (E1A binding protein p300) played a significant role in serial diseases
such as cancer, neurodegenerative disease. Therefore, it became a significant target …
such as cancer, neurodegenerative disease. Therefore, it became a significant target …
Fast rescoring protocols to improve the performance of structure-based virtual screening performed on protein–protein interfaces
N Singh, L Chaput, BO Villoutreix - Journal of chemical information …, 2020 - ACS Publications
Protein–protein interactions (PPIs) are attractive targets for drug design because of their
essential role in numerous cellular processes and disease pathways. However, in general …
essential role in numerous cellular processes and disease pathways. However, in general …
Reevaluation of bromodomain ligands targeting BAZ2A
G Cazzanelli, AD Vedove, E Parolin… - Protein …, 2023 - Wiley Online Library
BAZ2A promotes migration and invasion in prostate cancer. Two chemical probes, the
specific BAZ2‐ICR, and the BAZ2/BRD9 cross‐reactive GSK2801, interfere with the …
specific BAZ2‐ICR, and the BAZ2/BRD9 cross‐reactive GSK2801, interfere with the …
Exploring the role of Asp1116 in selective drug targeting of CREBcAMP-responsive element-binding protein implicated in prostate cancer
OE Akinsiku, OS Soremekun, FA Olotu… - … Chemistry & High …, 2020 - ingentaconnect.com
Background: The selective targeting of CREB-cAMP-responsive element-binding protein
(CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant …
(CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant …
Insights into interaction mechanism of inhibitors E3T, E3H and E3B with CREB binding protein by using molecular dynamics simulations and MM-GBSA calculations
SL Wu, J Zhao, HB Sun, HY Li, YY Yin… - SAR and QSAR in …, 2021 - Taylor & Francis
ABSTRACT CREB binding protein (CBP) and its paralog E1A binding protein (p300) are
related to the development of inflammatory diseases, cancers and other diseases, and have …
related to the development of inflammatory diseases, cancers and other diseases, and have …
Molecular dynamics insights into binding selectivity of inhibitors toward BRD4 and CBP
S Wu, L Wang, L Zhang, X Xu, J Zhao - Chemical Physics Letters, 2021 - Elsevier
Molecular dynamics (MD) simulations and binding free energy calculations were run to
explore binding selectivity of inhibitors F3J, EX1, and E2T toward bromodomain-containing …
explore binding selectivity of inhibitors F3J, EX1, and E2T toward bromodomain-containing …
[HTML][HTML] Molecular dynamics simulations data of six compounds F3J-BRD4/CBP, EX1-BRD4/CBP, and E2T-BRD4/CBP
S Wu, L Wang, L Zhang, X Xu, J Zhao - Data in Brief, 2021 - Elsevier
The data here described are related to the research article entitled “Molecular dynamics
insights into binding selectivity of inhibitors toward BRD4 and CBP”[1]. Bromodomain …
insights into binding selectivity of inhibitors toward BRD4 and CBP”[1]. Bromodomain …