NF-κB signaling pathways in osteoarthritic cartilage destruction

MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

N Fine, S Lively, CA Séguin, AV Perruccio… - Nature Reviews …, 2023 - nature.com
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Interplay between genetics and epigenetics in osteoarthritis

SJ Rice, F Beier, DA Young, J Loughlin - Nature Reviews …, 2020 - nature.com
Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

MicroRNA‐34a‐5p promotes joint destruction during osteoarthritis

H Endisha, P Datta, A Sharma… - Arthritis & …, 2021 - Wiley Online Library
Objective MicroRNA‐34a‐5p (miR‐34a‐5p) expression is elevated in the synovial fluid of
patients with late‐stage knee osteoarthritis (OA); however, its exact role and therapeutic …

[HTML][HTML] Osteoarthritis year in review 2019: genetics, genomics and epigenetics

LN Reynard, MJ Barter - Osteoarthritis and cartilage, 2020 - Elsevier
Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal …

E Ragni, A Papait, C Perucca Orfei… - Stem Cells …, 2021 - academic.oup.com
Human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) are easily
obtained in large quantities and free from ethical concerns. Promising therapeutic results for …

Secretome and extracellular vesicles as new biological therapies for knee osteoarthritis: a systematic review

D D'Arrigo, A Roffi, M Cucchiarini, M Moretti… - Journal of clinical …, 2019 - mdpi.com
Secretome and extracellular vesicles (EVs) are considered a promising option to exploit
mesenchymal stem cells'(MSCs) properties to address knee osteoarthritis (OA). The aim of …

Exploring the feasibility of circulating miRNAs as diagnostic and prognostic biomarkers in osteoarthritis: Challenges and opportunities

K Felekkis, M Pieri, C Papaneophytou - International Journal of Molecular …, 2023 - mdpi.com
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive
cartilage degradation and joint inflammation. As the most common aging-related joint …

Effect of dietary polyphenols on osteoarthritis—molecular mechanisms

M Sirše - Life, 2022 - mdpi.com
Osteoarthritis is a common crippling and degenerative disease resulting in irreversible
functional changes due to damage of the cartilage and other tissues of the joint. With limited …