Adiponectin: role in physiology and pathophysiology

TMD Nguyen - International journal of preventive medicine, 2020 - journals.lww.com
Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for
regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti …

Boosting extracellular vesicle secretion

L Debbi, S Guo, D Safina, S Levenberg - Biotechnology advances, 2022 - Elsevier
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a
promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID …

Inside (sight) of tiny communicator: exosome biogenesis, secretion, and uptake

AS Jadli, N Ballasy, P Edalat, VB Patel - Molecular and cellular …, 2020 - Springer
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …

Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

R Garcia-Martin, BB Brandao, T Thomou, E Altindis… - Cell reports, 2022 - cell.com
Exosomes/small extracellular vesicles (sEVs) can serve as multifactorial mediators of cell-to-
cell communication through their miRNA and protein cargo. Quantitative proteomic analysis …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

[HTML][HTML] Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

C Wang, Z Li, Y Liu, L Yuan - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry
many macromolecules from their parental cells and play important roles in intercellular …

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

I AlZaim, LPMH de Rooij, BN Sheikh… - Nature Reviews …, 2023 - nature.com
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

[HTML][HTML] Adiponectin stimulates exosome release to enhance mesenchymal stem-cell-driven therapy of heart failure in mice

Y Nakamura, S Kita, Y Tanaka, S Fukuda, Y Obata… - Molecular Therapy, 2020 - cell.com
Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside
in virtually all tissues, and the gain of MSCs by transplantation has become the leading form …

Extracellular vesicles in metabolic disease

N Akbar, V Azzimato, RP Choudhury, M Aouadi - Diabetologia, 2019 - Springer
Extracellular vesicles (EVs) are submicron-sized lipid envelopes that are produced and
released from a parent cell and can be taken up by a recipient cell. EVs are capable of …

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

A Blandin, I Dugail, G Hilairet, M Ponnaiah… - Cell reports, 2023 - cell.com
Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the
development of obesity-related metabolic dysfunctions. This study aims to define mouse …