The future clinical application of animal‐to‐human transplantation (xenotransplantation) is of
importance to society as a whole. Favourable preclinical data relevant to cell, tissue and …

Historically, human breast cancer has been modeled largely in vitro using long-established
cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of …

Within the last decade there have been several severe combined immunodeficient (SCID)
pig models discovered or genetically engineered. The animals have mutations in ARTEMIS …

Specific pathogen-free (SPF) animals are bred and managed to exclude pathogens
associated with significant morbidity or mortality that may secondarily pose a risk to public …

Mammary cancer, or breast cancer in women, is a polygenic disease with a complex
etiopathogenesis. While much remains elusive regarding its origin, it is well established that …

Coronary heart diseases are of high relevance for health care systems in developed
countries regarding patient numbers and costs. Disappointingly, the enormous effort put into …

Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal
model. Swine are anatomically and physiologically more similar to humans than mice …

Background Severe combined immunodeficient (SCID) pigs are an emerging animal model
being developed for biomedical and regenerative medicine research. SCID pigs can …

Swine biomedical models have been gaining in popularity over the last decade, particularly
for applications in oncology research. Swine models for cancer research include pigs that …

Ovarian cancer (OvCa) is the most lethal gynecologic malignancy, with two-thirds of patients
having late-stage disease (II-IV) at diagnosis. Improved diagnosis and therapies are …