Homocysteine and mitochondria in cardiovascular and cerebrovascular systems

P Kaplan, Z Tatarkova, MK Sivonova, P Racay… - International journal of …, 2020 - mdpi.com
Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Homocysteine modification in protein structure/function and human disease

H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts

CE Ekpenyong, E Akpan, A Nyoh - Chinese journal of natural medicines, 2015 - Elsevier
Cymbopogon citratus is a widely distributed perennial herb belonging to the Poaceae family
and has been extensively consumed for its medicinal, cosmetic, and nutritional effects for …

Folate and fetal programming: a play in epigenomics?

JL Guéant, F Namour, RM Gueant-Rodriguez… - Trends in Endocrinology …, 2013 - cell.com
Folate plays a key role in the interactions between nutrition, fetal programming, and
epigenomics. Maternal folate status influences DNA methylation, inheritance of the agouti …

Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms

M Ondičová, RE Irwin, SJ Thursby, L Hilman… - Clinical …, 2022 - Springer
Background We previously showed that continued folic acid (FA) supplementation beyond
the first trimester of pregnancy appears to have beneficial effects on neurocognitive …

[HTML][HTML] Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances

R Mallick, AK Duttaroy - Neurochemistry International, 2023 - Elsevier
Abstract Changes in gene expression are involved in many brain functions. Epigenetic
processes modulate gene expression by histone modification and DNA methylation or RNA …

Folate action in nervous system development and disease

OA Balashova, O Visina… - Developmental …, 2018 - Wiley Online Library
The vitamin folic acid has been recognized as a crucial environmental factor for nervous
system development. From the early fetal stages of the formation of the presumptive spinal …

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

M Mielcarek, D Zielonka, A Carnemolla… - Frontiers in cellular …, 2015 - frontiersin.org
For the past decade protein acetylation has been shown to be a crucial post-transcriptional
modification involved in the regulation of protein functions. Histone acetyltransferases …

Drug-induced megaloblastic anemia

CS Hesdorffer, DL Longo - New England Journal of Medicine, 2015 - Mass Medical Soc
Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12
absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a …