Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Mitophagy, which is a conserved cellular process for selectively removing damaged or
unwanted mitochondria, is critical for mitochondrial quality control and the maintenance of …

Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

Mitophagy is a type of selective macroautophagy/autophagy that degrades dysfunctional or
excessive mitochondria. Regulation of this process is critical for maintaining cellular …