Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Multifaceted regulation of MicroRNA biogenesis: essential roles and functional integration in neuronal and glial development

I Suster, Y Feng - International journal of molecular sciences, 2021 - mdpi.com
MicroRNAs (miRNAs) are small, non-coding RNAs that function as endogenous gene
silencers. Soon after the discovery of miRNAs, a subset of brain-enriched and brain-specific …

Evidence that C9ORF72 dipeptide repeat proteins associate with U2 snRNP to cause mis-splicing in ALS/FTD patients

S Yin, R Lopez-Gonzalez, RC Kunz, J Gangopadhyay… - Cell reports, 2017 - cell.com
Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide
repeat (DPR) proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis …

Chromatin-associated microprocessor assembly is regulated by the U1 snRNP auxiliary protein PRP40

A Stepien, J Dolata, T Gulanicz, D Bielewicz… - The Plant …, 2022 - academic.oup.com
In plants, microRNA (miRNA) biogenesis involves cotranscriptional processing of RNA
polymerase II (RNAPII)-generated primary transcripts by a multi-protein complex termed the …

Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture

M Bouvy-Liivrand, A Hernández de Sande… - Nucleic acids …, 2017 - academic.oup.com
Abstract Changes in mature microRNA (miRNA) levels that occur downstream of signaling
cascades play an important role during human development and disease. However, the …

Splicing noncoding RNAs from the inside out

L Yang - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
Eukaryotic precursor‐messenger RNAs (pre‐mRNAs) undergo splicing to remove intragenic
regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature …

Novel nuclear functions of Arabidopsis ARGONAUTE1: beyond RNA interference

M Bajczyk, SS Bhat, L Szewc… - Plant …, 2019 - academic.oup.com
Novel Nuclear Functions of Arabidopsis ARGONAUTE1: Beyond RNA Interference | Plant
Physiology | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

Emerging roles and potential applications of non-coding RNAs in glioblastoma

C DeOcesano-Pereira, RAC Machado… - International journal of …, 2020 - mdpi.com
Non-coding RNAs (ncRNAs) comprise a diversity of RNA species, which do not have the
potential to encode proteins. Non-coding RNAs include two classes of RNAs, namely: short …

The emerging role of microRNAs in polyglutamine diseases

X Dong, S Cong - Frontiers in Molecular Neuroscience, 2019 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding molecules that regulate a large amount of post-
transcriptional repressor genes by recognizing semi-complementary target sequences that …

HP1BP3, a chromatin retention factor for co-transcriptional microRNA processing

H Liu, C Liang, RK Kollipara, M Matsui, X Ke, BC Jeong… - Molecular cell, 2016 - cell.com
Recent studies suggest that the microprocessor (Drosha-DGCR8) complex can be recruited
to chromatin to catalyze co-transcriptional processing of primary microRNAs (pri-miRNAs) in …