Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …

Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Human immunodeficiency virus type 1 (HIV-1) assembly proceeds in two stages. First, the
55 kilodalton viral Gag polyprotein assembles into a hexameric protein lattice at the plasma …

The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

The major structural components of HIV are synthesized as a 55-kDa polyprotein, Gag.
Particle formation is driven by the self-assembly of Gag into a curved hexameric lattice, the …

Over the past several decades, extensive research into the Gag polyprotein, the main
structural protein of HIV-1 and all other retroviruses, has changed the way that we describe …

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte
(CTL) recognition is a major challenge for vaccine design. However, recent studies suggest …