Quantifying information of intracellular signaling: progress with machine learning
Y Tang, A Hoffmann - Reports on Progress in Physics, 2022 - iopscience.iop.org
Cells convey information about their extracellular environment to their core functional
machineries. Studying the capacity of intracellular signaling pathways to transmit information …
machineries. Studying the capacity of intracellular signaling pathways to transmit information …
Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics
Systems immunology lacks a framework with which to derive theoretical understanding from
high-dimensional datasets. We combined a robotic platform with machine learning to …
high-dimensional datasets. We combined a robotic platform with machine learning to …
Beyond normal: On the evaluation of mutual information estimators
Mutual information is a general statistical dependency measure which has found
applications in representation learning, causality, domain generalization and computational …
applications in representation learning, causality, domain generalization and computational …
Information transmission from NFkB signaling dynamics to gene expression
The dynamic signal encoding paradigm suggests that information flows from the
extracellular environment into specific signaling patterns (encoding) that are then read by …
extracellular environment into specific signaling patterns (encoding) that are then read by …
Decoding cellular communication: An information theoretic perspective on cytokine and endocrine signaling
F Schaper, T Jetka, A Dittrich - Current Opinion in Endocrine and Metabolic …, 2022 - Elsevier
Humoral communication is mediated by complex signaling pathways that are
heterogeneously activated in individual cells. According to Shannon's information theory …
heterogeneously activated in individual cells. According to Shannon's information theory …
The Mixtures and the Neural Critics: On the Pointwise Mutual Information Profiles of Fine Distributions
Mutual information quantifies the dependence between two random variables and remains
invariant under diffeomorphisms. In this paper, we explore the pointwise mutual information …
invariant under diffeomorphisms. In this paper, we explore the pointwise mutual information …
Mapping the dynamic transfer functions of eukaryotic gene regulation
JB Lee, LM Caywood, JY Lo, N Levering, AJ Keung - Cell systems, 2021 - cell.com
Biological information can be encoded within the dynamics of signaling components, which
has been implicated in a broad range of physiological processes including stress response …
has been implicated in a broad range of physiological processes including stress response …
The MAPK/ERK channel capacity exceeds 6 bit/hour
P Nałęcz-Jawecki, PA Gagliardi… - PLoS computational …, 2023 - journals.plos.org
Living cells utilize signaling pathways to sense, transduce, and process information. As the
extracellular stimulation often has rich temporal characteristics which may govern dynamic …
extracellular stimulation often has rich temporal characteristics which may govern dynamic …
Revealing hidden information in osteoblast's mechanotransduction through analysis of time patterns of critical events
G Ascolani, TM Skerry, D Lacroix, E Dall'Ara… - BMC …, 2020 - Springer
Background Mechanotransduction in bone cells plays a pivotal role in osteoblast
differentiation and bone remodelling. Mechanotransduction provides the link between …
differentiation and bone remodelling. Mechanotransduction provides the link between …
Modeling and measurement of signaling outcomes affecting decision making in noisy intracellular networks using machine learning methods
Abstract Characterization of decision-making in cells in response to received signals is of
importance for understanding how cell fate is determined. The problem becomes multi …
importance for understanding how cell fate is determined. The problem becomes multi …