Combinatorial approaches to the discovery of new functional molecules are well established
among chemists and biologists, inspired in large measure by the modular composition of …

Abstract Glycoside hydrolase family 18 (GH18) chitinases, which catalyze the
biodegradation of β-1, 4 glycosidic bond in amino polysaccharides via a substrate-assisted …

Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and
overexpression of this enzyme is also associated with several cancers and …

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …

This fundamental review article covers developments and applications in chiral separations
from January 2008 to January 2010 and is restricted to the English language literature …

Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive
peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's …

Currently, bioorthogonal coupling reactions have garnered considerable interest due to their
high substrate selectivity and less restrictive reaction conditions. During recent decades …

Chitinolytic enzymes are capable to catalyze the chitin hydrolysis. Due to their biomedical
and biotechnological applications, nowadays chitinolytic enzymes have attracted worldwide …

Over half of all antibiotics target the bacterial ribosome nature's complex, 2.5 MDa
nanomachine responsible for decoding mRNA and synthesizing proteins. Macrolide …