Ageing is accompanied by 2–4-fold increases in plasma/serum levels of inflammatory
mediators such as cytokines and acute phase proteins. A wide range of factors seems to …

Studies have demonstrated that circulating levels of plasma cytokines are influenced greatly
by age and that chronic elevated levels of certain cytokines are associated with chronic …

Age-related macular degeneration (AMD) is a disease of the outer retina, characterized most
significantly by atrophy of photoreceptors and retinal pigment epithelium accompanied with …

[Frontiers in Bioscience 7, d1056-1183, May 1, 2002] 1056 T CELLS AND AGING,
JANUARY 2002 UPDATE Graham Pawelec1, Yvonne Barnett Page 1 [Frontiers in …

Current evidence strongly indicates that reactive oxygen species (ROS) and reactive
nitrogen species (RNS) are widely implicated in the inflammatory process. However …

Accumulating evidence strongly suggests that oxidative stress underlies aging processes.
Research provides consistent evidence that calorie restriction (CR) reduces age‐related …

PURPOSE: Aging is accompanied by a progressive increase in pro-inflammatory cytokine
status. However, little is known about the development of age-dependent modifications in …

We previously reported that aging F344XBN rats are more vulnerable to disruptions of
memory consolidation processes following an injection of Escherichia coli than are young …

Background Immunosenescence is related to the deterioration of many immune functions,
which may be manifested in increased susceptibility to infection, cancer, and autoimmunity …

This study was designed to define the lipopolysaccharide (LPS) sensitivity of aged mice in
terms of lethality and cytokine production and to determine down-regulating responses of …