Scorpion venom components as potential candidates for drug development
E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …
for human beings, including death. Neurotoxins present in their venoms are responsible for …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
[HTML][HTML] Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
Tityus serrulatus sting causes thousands of deaths annually worldwide. T. serrulatus-
envenomed victims exhibit local or systemic reaction that culminates in pulmonary oedema …
envenomed victims exhibit local or systemic reaction that culminates in pulmonary oedema …
Tityus serrulatus venom–a lethal cocktail
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom
is composed of several compounds such as mucus, inorganic salts, lipids, amines …
is composed of several compounds such as mucus, inorganic salts, lipids, amines …
[HTML][HTML] Biological effects of animal venoms on the human immune system
Z Avalo, MC Barrera, M Agudelo-Delgado, GJ Tobón… - Toxins, 2022 - mdpi.com
Venoms are products of specialized glands and serve many living organisms to immobilize
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
[HTML][HTML] Immunological responses to envenomation
Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the
consequences of envenomation range from self-limiting to lethal. Critical host defence …
consequences of envenomation range from self-limiting to lethal. Critical host defence …
[HTML][HTML] Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
MB Reis, FL Rodrigues, N Lautherbach… - Nature …, 2020 - nature.com
Scorpion envenomation is a leading cause of morbidity and mortality among accidents
caused by venomous animals. Major clinical manifestations that precede death after …
caused by venomous animals. Major clinical manifestations that precede death after …
Scorpion envenomation and inflammation: Beyond neurotoxic effects
Scorpion envenomation results in a wide range of clinical manifestations that are mostly
attributed to the activation of the autonomic nervous system by venom toxins. In fact …
attributed to the activation of the autonomic nervous system by venom toxins. In fact …
[HTML][HTML] CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against …
TR Costa, DL Menaldo, KF Zoccal, SM Burin… - Scientific Reports, 2017 - nature.com
L-amino acid oxidases from snake venoms have been described to possess various
biological functions. In this study, we investigated the inflammatory responses induced in …
biological functions. In this study, we investigated the inflammatory responses induced in …
[HTML][HTML] A Complex Pattern of Gene Expression in Tissue Affected by Viperid Snake Envenoming: The Emerging Role of Autophagy-Related Genes
Viperid snake venoms induce severe tissue damage, characterized by the direct toxic action
of venom components, ie, phospholipases A2 (PLA2s) and metalloproteinases (SVMPs) …
of venom components, ie, phospholipases A2 (PLA2s) and metalloproteinases (SVMPs) …