Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies.
However, its primary dose‐limiting side effect is kidney injury, which is a major clinical …

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The
most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the …

Sex and age influence susceptibility to acute kidney injury (AKI), with young females
exhibiting lowest incidence. In these studies, we investigated mechanisms which may …

Aims Cisplatin (CP) is an antineoplastic widely used in the treatment of various solid tumors,
however, its clinical application is limited by nephrotoxicity. Here, we compared the impact of …

Background: One of the main therapeutic limitations of cisplatin (CP) is nephrotoxicity which
is time-dependent. Objectives: The purpose of this study was to determine the optimal timing …

Gender is one of the essential factors in the development of various diseases and poisoning.
Therefore, we herein examined gender differences in sodium arsenite (NaAsO 2)-induced …

Background: Renal ischemia-reperfusion (RIR) is the main cause of renal failure. The
incidence of RIR injury seems to be gender-related due to female sex hormone; estrogen …

Menopause is an important physiological event associated with structural and functional
changes in the kidneys. An animal model of bilateral ovariectomy was used to study the …

Background: A sex difference in cisplatin-induced nephrotoxicity (CIN) has been reported in
human and animal studies. We examined in humans whether it is associated with sex …

Ototoxicity is a well-known side effect of cisplatin. Some genetic and non-genetic risk factors
were described for cisplatin ototoxicity. Although there are some studies which point out a …