Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …

Simple Summary Glioblastoma is one of the deadliest brain cancers, and despite the efforts
made in the last few years, the life expectancy of patients is still low. In most cases, even with …

Stemness reprogramming remains a largely unaddressed principal cause of lethality in
glioblastoma (GBM). It is therefore of utmost importance to identify and target mechanisms …

Introduction: Drug-based treatment regimens for cancer are often associated with off-target
toxic side effects and low penetration of the drug at the tumor site leading to patient morbidity …

The hijacking of early developmental programs is a canonical feature of gliomas where
neoplastic cells resemble neurodevelopmental lineages and possess mechanisms of stem …

Understanding mechanisms of cancer development is mandatory for disease prevention
and management. In healthy tissue, the microenvironment or niche governs stem cell fate by …

Simple Summary Glioblastoma (GBM) is the most aggressive form of glioma (WHO grade
IV), and mounting evidence suggests that glioblastoma stem-like cells (GSCs) play an …

Embryonic stem cells and induced pluripotent stem cells provided us with fascinating new
knowledge in recent years. Mechanistic insight into intricate regulatory circuitry governing …

Confounding results of engineered mesenchymal stem cells (MSCs) used as cellular
vehicles has plagued technologies whereby success or failure of novel approaches may be …

Wnts, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF) are paracrine
signaling pathways implicated in the niche control of stem cell fate decisions. BMP-on and …