Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …

Introduction Naïve T cells remain in an actively maintained state of quiescence until
activation by antigenic signals, upon which they start to proliferate and generate effector …

Bioactivities of fucoidan, a class of marine algal polysaccharides, vary depending on the
original algal species. The aim of this study was to explore the in vivo immunomodulatory …

Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and
revolutionized the paradigm of tumor treatment, while substantial patients remain …

Abstract Costimulatory domains (CSD) of 4-1BB and CD28 are most widely used in chimeric
antigen receptor (CAR)–engineered T cells. These CAR T cells have shown encouraging …

Immunotherapy has now garnered significant attention as an essential component in cancer
therapy during this new era. However, due to immune tolerance, immunosuppressive …

Atherosclerosis is a key pathological basis for cardiovascular diseases, significantly
influenced by T-cell-mediated immune responses. T-cells differentiate into various subtypes …

INTRODUCTION: Naïve T cells remain in an actively maintained state of quiescence until
activation by antigenic signals, upon which they start to proliferate and generate effector …

Cancer treatment era has been revolutionized by the novel therapeutic methods such as
immunotherapy in recent years. Immunotherapy-based approaches are considered effective …