Tumor‐associated macrophages in liver cancer: from mechanisms to therapy
K Cheng, N Cai, J Zhu, X Yang, H Liang… - Cancer …, 2022 - Wiley Online Library
Multidimensional analyses have demonstrated the presence of a unique tumor
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …
[HTML][HTML] Determinants of resident tissue macrophage identity and function
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …
Deciphering human macrophage development at single-cell resolution
Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate developing organs, where they …
development. In mice, embryonic macrophages infiltrate developing organs, where they …
Tissue resident CCR2− and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury
Rationale: Recent advancements have brought to light the origins, complexity, and functions
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …
Early fate defines microglia and non-parenchymal brain macrophage development
Central nervous system (CNS) macrophages comprise microglia and border-associated
macrophages (BAMs) residing in the meninges, the choroid plexus, and the perivascular …
macrophages (BAMs) residing in the meninges, the choroid plexus, and the perivascular …
Fetal monocytes and the origins of tissue-resident macrophages
Tissue-resident macrophages have pivotal functions for tissue defense and homeostasis.
Two main discoveries have changed our current understanding of macrophage …
Two main discoveries have changed our current understanding of macrophage …
The biphasic function of microglia in ischemic stroke
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …
yolk sac. Microglia can be activated within hours and recruited to the lesion site …
[HTML][HTML] C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from
embryonic precursors that seed the tissues prior to birth to generate a self-renewing …
embryonic precursors that seed the tissues prior to birth to generate a self-renewing …
Origin and functions of tissue macrophages
S Epelman, KJ Lavine, GJ Randolph - Immunity, 2014 - cell.com
Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …
homeostasis and disease. Recently, it has become evident that most adult tissue …
Regulation of macrophage development and function in peripheral tissues
Macrophages are immune cells of haematopoietic origin that provide crucial innate immune
defence and have tissue-specific functions in the regulation and maintenance of organ …
defence and have tissue-specific functions in the regulation and maintenance of organ …