Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists

S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Contribution of adaptive immunity to human COPD and experimental models of emphysema

F Kheradmand, Y Zhang, DB Corry - Physiological Reviews, 2023 - journals.physiology.org
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis

R Subbiah, RR Tiwari - Critical reviews in Toxicology, 2021 - Taylor & Francis
Abstract The herbicide paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridylium dichloride) is a highly
toxic organic heterocyclic herbicide that has been widely used in agricultural settings. Since …

Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms

MA Khan, ZA Khan, M Charles, P Pratap… - Journal of …, 2021 - Taylor & Francis
Mucus is an integral part of the respiratory physiology. It protects the respiratory tract by
acting as a physical barrier against inhaled particles and microbes. Excessive inflammation …

Vitamin D and its therapeutic relevance in pulmonary diseases

S Ahmad, S Arora, S Khan, M Mohsin, A Mohan… - The Journal of …, 2021 - Elsevier
Vitamin D is customarily involved in maintaining bone and calcium homeostasis. However,
contemporary studies have identified the implication of vitamin D in several cellular …

Alternaria as an Inducer of Allergic Sensitization

G Hernandez-Ramirez, D Barber, J Tome-Amat… - Journal of Fungi, 2021 - mdpi.com
Alternaria alternata is a saprophytic mold whose spores are disseminated in warm dry air,
the typical weather of the Mediterranean climate region (from 30° to 45°), with a peak during …

TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2

D Kaushik, R Bhandari, A Kuhad - Expert Opinion on Therapeutic …, 2021 - Taylor & Francis
Introduction: The COVID-19 pandemic remains aglobal challenge. While there are mRNA
agents on the horizon as apotential prevention, adefinitive drug therapy is an unmet medical …

Immunopathogenicity of Acanthamoeba spp. in the Brain and Lungs

K Kot, N Łanocha-Arendarczyk… - International Journal of …, 2021 - mdpi.com
Free-living amoebas, including Acanthamoeba spp., are widely distributed in soil, water, and
air. They are capable of causing granulomatous amebic encephalitis, Acanthamoeba …

Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization

X Li, Y Wei, S Li, J Liang, Z Liu, Y Cui, J Gao… - International …, 2022 - Elsevier
Acute lung injury (ALI) is a disease characterized by pulmonary diffusion dysfunction and its
exacerbation stage is acute respiratory distress syndrome (ARDS), which may develop to …