[HTML][HTML] Radiomics and artificial intelligence for precision medicine in lung cancer treatment

M Chen, SJ Copley, P Viola, H Lu… - Seminars in cancer biology, 2023 - Elsevier
Lung cancer is the leading cause of cancer-related deaths worldwide. It exhibits, at the
mesoscopic scale, phenotypic characteristics that are generally indiscernible to the human …

Identification and application of emerging biomarkers in treatment of non-small-cell lung cancer: systematic review

JC Restrepo, D Martínez Guevara, A Pareja López… - Cancers, 2024 - mdpi.com
Simple Summary Lung cancer remains a leading cause of cancer-related mortality globally,
requiring new diagnostic and therapeutic approaches. This research arises from the need to …

[HTML][HTML] Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma

P Chen, FR Rojas, X Hu, A Serrano, B Zhu, H Chen… - Modern Pathology, 2023 - Elsevier
Recent statistics on lung cancer, including the steady decline of advanced diseases and the
dramatically increasing detection of early-stage diseases and indeterminate pulmonary …

Evaluation of PD-L1 Expression Level in Patients With Non-Small Cell Lung Cancer by 18F-FDG PET/CT Radiomics and Clinicopathological Characteristics

J Li, S Ge, S Sang, C Hu, S Deng - Frontiers in Oncology, 2021 - frontiersin.org
Purpose In the present study, we aimed to evaluate the expression of programmed death-
ligand 1 (PD-L1) in patients with non-small cell lung cancer (NSCLC) by radiomic features of …

[HTML][HTML] Independent prognostic implications of RRM2 in lung adenocarcinoma

C Ma, H Luo, J Cao, C Gao, X Fa, G Wang - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Background: Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is the catalytic
subunit of ribonucleotide reductase and modulates the enzymatic activity, which is essential …

Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma

Q Cheng, W Zhao, X Song, T Jin - Genes & Immunity, 2024 - nature.com
Lung cancer is a major cause accounting for cancer-related mortalities, with lung
adenocarcinoma (LUAD) being the most prevalent subtype. Given the high clinical and …

Imbalanced data correction based PET/CT radiomics model for predicting lymph node metastasis in clinical stage T1 lung adenocarcinoma

J Lv, X Chen, X Liu, D Du, W Lv, L Lu, H Wu - Frontiers in Oncology, 2022 - frontiersin.org
Objectives To develop and validate the imbalanced data correction based PET/CT radiomics
model for predicting lymph node metastasis (LNM) in clinical stage T1 lung adenocarcinoma …

Unraveling the expression patterns of immune checkpoints identifies new subtypes and emerging therapeutic indicators in lung adenocarcinoma

J Zhang, X Han, L Lin, J Chen, F Wang… - Oxidative medicine …, 2022 - Wiley Online Library
Immune checkpoint genes (ICGs) play pivotal roles in tumor immune microenvironment
(TIME), and thus, targeting them represents a promising strategy for cancer immunotherapy …

Targeting HER3 to overcome EGFR TKI resistance in NSCLC

Q Chen, G Jia, X Zhang, W Ma - Frontiers in Immunology, 2024 - frontiersin.org
Receptor tyrosine kinases (RTKs) play a crucial role in cellular signaling and oncogenic
progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have …

Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics

Vikas, HK Sahu, AK Mehata, MK Viswanadh… - …, 2022 - Taylor & Francis
Cancer is the leading cause of mortality worldwide. Among all cancer types, lung cancer is
recognized as the most lethal and highly metastatic. The application of targeted …