A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

RS Keri, MR Patil, SA Patil, S Budagumpi - European Journal of Medicinal …, 2015 - Elsevier
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …

Recent advances in the chemistry and biology of benzothiazoles

RK Gill, RK Rawal, J Bariwal - Archiv der Pharmazie, 2015 - Wiley Online Library
Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five‐
membered thiazole ring. This moiety has attracted considerable attention because of its …

Therapeutic advancement of benzothiazole derivatives in the last decennial period

S Tariq, P Kamboj, M Amir - Archiv der Pharmazie, 2019 - Wiley Online Library
Benzothiazole, a fused heterocyclic moiety, has attracted synthetic and medicinal chemists
for good reasons. It is a valuable scaffold that possesses diverse biological activities, such …

Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity

PC Diao, WY Lin, XE Jian, YH Li, WW You… - European Journal of …, 2019 - Elsevier
To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based
benzothiazole derivatives were designed and synthesized. Initial biological evaluation …

Importance of fluorine in benzazole compounds

T Al-Harthy, W Zoghaib, R Abdel-Jalil - Molecules, 2020 - mdpi.com
Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …

[HTML][HTML] Synthesis, characterization, biological studies, molecular docking and theoretical calculation of some transition metal complexes with new azo dye 2-[2′-(6 …

KJ Al-Adilee, HAK Kyhoiesh, AM Taher - Results in Chemistry, 2022 - Elsevier
Abstract Ag (I), Pt (IV), and Au (III) metal complexes of novel ligand 2-[2′-(6-
methoxybenzothiazolyl) azo]-3-methyl-4-nitro phenol (6-MBTAMN) have been synthesized …

Synthetic and medicinal perspective of fused-thiazoles as anticancer agents

S Pawar, K Kumar, MK Gupta… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer is second leading disease after cardiovascular disease. Presently,
Chemotherapy, Radiotherapy and use of chemicals are some treatments available these …

Recent advances on anticancer and antimicrobial activities of directly-fluorinated five-membered heterocycles and their benzo-fused systems

AA Abbas, TA Farghaly, KM Dawood - RSC advances, 2024 - pubs.rsc.org
Due to the importance of the fluorinated heterocycles as main components of marketed
drugs where 20% of the anticancer and antibiotic drugs contain fluorine atoms, this review …

In the pursuit of novel therapeutic agents: synthesis, anticancer evaluation, and physicochemical insights of novel pyrimidine-based 2-aminobenzothiazole derivatives

TI Ismail, N El-Khazragy, RA Azzam - RSC advances, 2024 - pubs.rsc.org
Cancer remains a worldwide healthcare undertaking, demanding continual innovation in
anticancer drug development due to frequent drug resistance and adverse effects …

Benzothiazole: Synthetic strategies, biological potential, and interactions with targets

C Singh, R Kumar, A Mazumder… - Mini-Reviews in …, 2022 - benthamdirect.com
Benzothiazole is a heterocyclic compound that contains a benzene ring fused with a
fivemember 1, 3-thiazole ring. Several types of research have established its potential as an …