Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

'The development of a multicellular organism from a single egg cell requires both the
determination of many cell types and the organization of these cells into an elaborate pattern …

We have identified two distinct mechanisms initiating the adhesion of flowing platelets to
thrombogenic surfaces. The integrin α IIb β 3 promotes immediate arrest onto fibrinogen but …

We have used confocal videomicroscopy in real time to delineate the adhesive interactions
supporting platelet thrombus formation on biologically relevant surfaces. Type I collagen …

Exposure of platelets to shear stress leads to aggregation in the absence of exogenous
agonists. We have now found that different adhesive proteins and platelet membrane …

Integrins regulate cell adhesion and motility through tyrosine kinases, but initiation of this
process is poorly understood. We find here that Src associates constitutively with integrin …

The leucine-rich repeat structure was first noticed in the primary sequence of leucinerich u2-
glycoprotein (LRG) of human serum (Takahashi et aL, 1985). This protein was so named …

When a blood vessel is injured, control of bleeding starts with the rapid adhesion of
circulating platelets to the site of damage. Within seconds, the adhered platelets are …

We have studied the mechanism of interaction between soluble von Willebrand factor (vWF),
labeled with fluorescein isothiocyanate (FITC), and platelets exposed to shear in a cone-and …

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets,
glycoprotein (GP) Ib–IX receptor complex has been long suggested to be a shear sensor …