Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding
of gene function in the post-genomic era. Proteomics can be divided into three main …

In this postgenomic era, there is a specific need to assign function to orphan genes in order
to validate potential targets for drug therapy and to discover new biomarkers of disease …

Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …

Due to the rapid release of new data from genome sequencing projects, the majority of
protein sequences in public databases have not been experimentally characterized; rather …

The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996.
Soon after these breakthroughs, an exponential rate of genome sequencing was …

1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …

The methodologies used to generate genome and metagenome annotations are diverse
and vary between groups and laboratories. Descriptions of the annotation process are …

While the number of sequenced genomes continues to grow, experimentally verified
functional annotation of whole genomes remains patchy. Structural genomics projects are …

High-throughput technologies impress us almost every week with novel global results and
big numbers. They often reveal important general trends that are impossible to realize with …

Proteins function mainly through interactions, especially with DNA and other proteins. While
some large-scale interaction networks are now available for a number of model organisms …