TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

J Wu, Z Feng, L Chen, Y Li, H Bian, J Geng… - Nature …, 2022 - nature.com
Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the
accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts …

[PDF][PDF] Rheumatoid arthritis-associated interstitial lung disease: epidemiology, risk/prognostic factors, and treatment landscape

MS Fazeli, V Khaychuk, K Wittstock, X Han… - Clin Exp …, 2021 - clinexprheumatol.org
Objective. To summarise the epidemiology, risk and prognostic factors, and treatment
landscape of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Methods …

Age-related mechanisms in the context of rheumatic disease

G Alsaleh, FC Richter, AK Simon - Nature Reviews Rheumatology, 2022 - nature.com
Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

The risk of infections associated with JAK inhibitors in rheumatoid arthritis: a systematic review and network meta-analysis

C Alves, A Penedones, D Mendes… - JCR: Journal of Clinical …, 2022 - journals.lww.com
Methods PubMed, EMBASE, Cochrane Library, and clinicaltrials. gov were searched to
identify randomized controlled trials evaluating the efficacy and safety of JAK inhibitors in …

Small molecule inhibitors in the treatment of rheumatoid arthritis and beyond: Latest updates and potential strategy for fighting COVID-19

M Massalska, W Maslinski, M Ciechomska - Cells, 2020 - mdpi.com
The development of biological disease-modifying antirheumatic drugs (bDMARDs) and
target synthetic DMARDs (tsDMARDs), also known as small molecule inhibitors, represent a …

[PDF][PDF] Online management of rheumatoid arthritis during COVID-19 pandemic

Y Zhang, J Wang, L Zhao, J Xiao, Z Shi - Annals of the Rheumatic …, 2020 - ard.bmj.com
We have read with great interest the recent article from Figueroa-Parra et al 1 entitled 'Are
my patients with rheumatic diseases at higher risk of COVID-19?'We agree that patients with …

Combinatory Effects of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant‐Induced Arthritis in Wistar Rats: Roles of IL‐1β, IL‐4, Nrf‐2 …

EA Ahmed, OM Ahmed, HI Fahim… - Evidence‐Based …, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with
chronic inflammation and severe disability. Bone Marrow‐derived Mesenchymal Stem Cells …

Potency of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund's Adjuvant‐Induced Arthritic Rats: Roles of TNF‐α, IL‐10, iNOS, MMP‐9, and …

EA Ahmed, OM Ahmed, HI Fahim, TM Ali… - Stem Cells …, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune syndrome affecting joint spaces, leading to the
disabled state. Currently, there is no optimal therapy for RA except for systemic …

[PDF][PDF] Central sensitisation features are associated with neuropathic pain-like symptoms in patients with longstanding rheumatoid arthritis: a cross-sectional study …

M Saitou, K Noda, T Matsushita, T Ukichi… - Clin Exp …, 2022 - clinexprheumatol.org
Objective Several studies have indicated that arthralgia may be driven by central
sensitisation. Central sensitivity syndrome (CSS) is a concept that unifies various symptoms …

A Novel Hydroxyapatite/Vitamin B12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant …

A Belal, R Mahmoud, EE Mohamed, A Farghali… - Pharmaceuticals, 2023 - mdpi.com
The usage of nanomaterials for rheumatoid arthritis (RA) treatment can improve
bioavailability and enable selective targeting. The current study prepares and evaluates the …