[HTML][HTML] DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects
Copy number variants (CNVs) were the subject of extensive research in the past years. They
are common features of the human genome that play an important role in evolution …
are common features of the human genome that play an important role in evolution …
Hereditary nonpolyposis colorectal cancer and cancer syndromes: recent basic and clinical discoveries
E Chen, X Xu, T Liu - Journal of oncology, 2018 - Wiley Online Library
Approximately one‐third of individuals diagnosed with colorectal cancer have a family
history of cancer, suggesting that CRCs may result from a heritable component. Despite the …
history of cancer, suggesting that CRCs may result from a heritable component. Despite the …
Evolution and function of developmentally dynamic pseudogenes in mammals
Background Pseudogenes are excellent markers for genome evolution, which are emerging
as crucial regulators of development and disease, especially cancer. However, systematic …
as crucial regulators of development and disease, especially cancer. However, systematic …
The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying …
Background Colorectal cancer is the third most common cancer in the world. In this study,
we assessed the long-term survival characteristics and prognostic associations and …
we assessed the long-term survival characteristics and prognostic associations and …
[HTML][HTML] Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts
Z Zeng, Y Gao, J Li, G Zhang, S Sun, Q Wu… - Computational and …, 2022 - Elsevier
Background Cox proportional hazard regression (CPH) model relies on the proportional
hazard (PH) assumption: the hazard of variables is independent of time. CPH has been …
hazard (PH) assumption: the hazard of variables is independent of time. CPH has been …
[HTML][HTML] DPY30 promotes proliferation and cell cycle progression of colorectal cancer cells via mediating H3K4 trimethylation
WC Su, XM Mao, SY Li, CY Luo, R Fan… - … journal of medical …, 2023 - ncbi.nlm.nih.gov
DPY30, a core subunit of the SET1/MLL histone H3K4 methyltransferase complexes, plays
an important role in diverse biological functions through the epigenetic regulation of gene …
an important role in diverse biological functions through the epigenetic regulation of gene …
A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer
Y Yu, S Werdyani, M Carey, P Parfrey… - Molecular …, 2021 - Wiley Online Library
We aimed to examine the associations of a genome‐wide set of single nucleotide
polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions …
polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions …
Long-insert sequence capture detects high copy numbers in a defence-related beta-glucosidase gene βglu-1 with large variations in white spruce but not Norway …
Conifers are long-lived and slow-evolving, thus requiring effective defences against their fast-
evolving insect natural enemies. The copy number variation (CNV) of two key acetophenone …
evolving insect natural enemies. The copy number variation (CNV) of two key acetophenone …
Concordance rate between copy number variants detected using either high-or medium-density single nucleotide polymorphism genotype panels and the potential of …
Background The trading of individual animal genotype information often involves only the
exchange of the called genotypes and not necessarily the additional information required to …
exchange of the called genotypes and not necessarily the additional information required to …
Characterization of copy number variants in a large multibreed population of beef and dairy cattle using high-density single nucleotide polymorphism genotype data
P Rafter, DC Purfield, DP Berry… - Journal of Animal …, 2018 - academic.oup.com
Copy number variants (CNV s) are a form of genomic variation that changes the structure of
the genome through deletion or duplication of stretches of DNA. The objective of the present …
the genome through deletion or duplication of stretches of DNA. The objective of the present …