Chromosomal instability in genome evolution: From cancer to macroevolution
V Comaills, M Castellano-Pozo - Biology, 2023 - mdpi.com
Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
The spatial folding of chromosomes inside the nucleus has regulatory effects on gene
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …
The localization of centromere protein A is conserved among tissues
E Cappelletti, FM Piras, L Sola, M Santagostino… - Communications …, 2023 - nature.com
Centromeres are epigenetically specified by the histone H3 variant CENP-A. Although
mammalian centromeres are typically associated with satellite DNA, we previously …
mammalian centromeres are typically associated with satellite DNA, we previously …
Molecular dynamics and evolution of centromeres in the genus equus
FM Piras, E Cappelletti, M Santagostino… - International journal of …, 2022 - mdpi.com
The centromere is the chromosomal locus essential for proper chromosome segregation.
While the centromeric function is well conserved and epigenetically specified, centromeric …
While the centromeric function is well conserved and epigenetically specified, centromeric …
Robertsonian fusion and centromere repositioning contributed to the formation of satellite-free centromeres during the evolution of zebras
E Cappelletti, FM Piras, L Sola… - Molecular Biology …, 2022 - academic.oup.com
Centromeres are epigenetically specified by the histone H3 variant CENP-A and typically
associated with highly repetitive satellite DNA. We previously discovered natural satellite …
associated with highly repetitive satellite DNA. We previously discovered natural satellite …
A Satellite-Free Centromere in Equus przewalskii Chromosome 10
FM Piras, E Cappelletti, WA Abdelgadir… - International journal of …, 2023 - mdpi.com
In mammals, centromeres are epigenetically specified by the histone H3 variant CENP-A
and are typically associated with satellite DNA. We previously described the first example of …
and are typically associated with satellite DNA. We previously described the first example of …
Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution
A Ruiz-Herrera, PD Waters - Heredity, 2022 - nature.com
Sex-linked inheritance is a stark exception to Mendel's Laws of Heredity. Here we discuss
how the evolution of heteromorphic sex chromosomes (mainly the Y) has been shaped by …
how the evolution of heteromorphic sex chromosomes (mainly the Y) has been shaped by …
Decoding the equine genome: lessons from ENCODE
The horse reference genome assemblies, EquCab2. 0 and EquCab3. 0, have enabled great
advancements in the equine genomics field, from tools to novel discoveries. However …
advancements in the equine genomics field, from tools to novel discoveries. However …
Population scale analysis of centromeric satellite DNA reveals highly dynamic evolutionary patterns and genomic organization in long-tailed and rhesus macaques
Centromeric satellite DNA (cen-satDNA) consists of highly divergent repeat monomers, each
approximately 171 base pairs in length. Here, we investigated the genetic diversity in the …
approximately 171 base pairs in length. Here, we investigated the genetic diversity in the …
CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres
E Cappelletti, FM Piras, M Biundo, E Raimondi… - bioRxiv, 2024 - biorxiv.org
Background While CENP-A is the epigenetic determinant of the centromeric function, the
role of CENP-B, the sole centromeric protein binding a specific DNA sequence (CENP-B …
role of CENP-B, the sole centromeric protein binding a specific DNA sequence (CENP-B …